Testosterone Replacement Therapy

Benefits of TRT

Effectively treating hypogonadism can have significantly improve a patient’s sense of wellbeing and quality of life.

TRT can improve: 1, 2-7

  • Sexual function
  • Sexual desire and performance
  • Muscle strength and mass
  • Bone density
  • Wellbeing and mood
  • Erythropoiesis
  • Cognition
  • Response to PDE5 inhibitors

Lipid abnormalities

  • Dose dependent reduction in HDL, LDL and total cholesterol

Glucose metabolism

  • Reduction in glucose level and insulin resistance
  • Improved insulin sensitivity
  • Decreased leptin levels in T2DM and metabolic syndrome


  • Reduced body fat mass and waist circumference
  • Appropriate fat distribution
  • Improved BMI
  • Improved lean body mass

Types of TRT

TRT is available in the form of injections, gels, implants, patches, capsules and tablets; all of which differ in terms of pharmacokinetics and adverse events.

Short-acting preparations such as gels are recommended by the EAU over long acting injections when initiating treatment, as therapy can be adjusted or stopped in response to adverse side-effects.3-13

Gels and injections are more commonly used, but ultimately, selection should be based on safety, tolerability, efficacy and patient preference.

TRT formulation comparisons

Advantages of different methods of administration1, 14-19

Disadvantages of different methods of administration1, 14-19

More information on diagnosing and treating
hypogonadism can be found in the European Association
of Urology Guidelines
on male hypogonadism.